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Target intelligence / Profile preview
Macrophage Scavenger Receptor Type A (SR-A)
- Target
- SR-A
- Molecular classification
- Receptor, Scavenger Receptor, Pattern Recognition Receptor (PRR), Membrane Glycoprotein
01
Overview
The macrophage scavenger receptor type A (SR-A) is a trimeric membrane glycoprotein that functions as a pattern recognition receptor in innate immunity and plays a crucial role in lipid metabolism, particularly in the development of atherosclerosis. It is predominantly expressed on tissue macrophages and mediates the uptake of modified lipoproteins, pathogens, and apoptotic cells. Emerging research suggests a role in cancer biology and immunology, making it a potential therapeutic target.
- Other names
- MSR1Scavenger receptor class A member 1SR-AISR-AIISR-AIII
02
Mechanism of action
Modulation of SR-A activity is being explored as a therapeutic strategy, but specific drugs directly targeting it are still under development.
03
Biological functions
Lipid metabolismPathogen recognitionInnate immunityAdaptive immune responseClearance of apoptotic cellsClearance of beta-amyloid peptideClearance of anionic phospholipidsClearance of advanced glycation end-products (AGEs)Immune regulationAdhesion
04
Disease associations
AtherosclerosisCancerInfectionInflammationAlzheimer's Disease
05
Safety considerations
Potential for off-target effects due to broad ligand specificityModulation of immune responses could have unintended consequencesInducing macrophage apoptosis
06
Biomarkers
SR-A expression levels in macrophages as a potential diagnostic biomarker for atherosclerosis and certain cancers
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