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Target intelligence / Profile preview
Macrophage Stimulating 1 Receptor (RON)
- Target
- RON
- Molecular classification
- Receptor tyrosine kinase (RTK), Receptor
01
Overview
The Macrophage Stimulating 1 Receptor (MST1R/RON) is a receptor tyrosine kinase involved in regulating inflammation, host defense, and cell migration/differentiation. It is activated by macrophage-stimulating protein (MSP), leading to downstream signaling through pathways like PI3K/AKT/mTOR and β-catenin. RON overexpression or mutation is associated with several cancers, making it a therapeutic target.
- Other names
- Recepteur d'Origine NantaisCD136p185-RonPTK8SEA
02
Mechanism of action
Inhibition of RON kinase activity; antibody-mediated receptor blockade
03
Biological functions
Regulation of inflammationHost defenseCell migrationCell differentiationSignal transductionCell proliferation
04
Disease associations
CancerInflammation
05
Biomarkers
RON overexpression in breast cancer (prognostic for metastatic progression)
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