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Target intelligence / Profile preview
Recepteur d'Origine Nantais (RON)
- Target
- RON
- Molecular classification
- Receptor, Receptor tyrosine kinase (RTK), MET proto-oncogene family
01
Overview
Recepteur d'Origine Nantais (RON), also known as MST1R or Macrophage-stimulating protein receptor, is a receptor tyrosine kinase belonging to the MET proto-oncogene family. Upon activation by its ligand MSP/HGFL, RON mediates cellular processes such as cell adhesion, invasion, motility, and apoptosis regulation. Aberrant expression and activation of RON are implicated in tumor progression and metastasis, making it a therapeutic target for various cancers. Anti-RON antibody-drug conjugates are under investigation.
- Other names
- MST1RMacrophage-stimulating protein receptor
02
Mechanism of action
Tyrosine kinase inhibition (potential mechanism for therapeutic interventions)
03
Biological functions
Cell adhesionInvasionMotilityApoptosis regulationSignal transductionCell proliferation
04
Disease associations
CancerTumor progressionMetastasis
05
Safety considerations
Potential for off-target effects due to similarity to other RTKsDevelopment of resistanceToxicity associated with antibody-drug conjugates
06
Biomarkers
RON expression levels in tumorsMSP/HGFL levels
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