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Macular Pigment (MP)
- Target
- MP
- Molecular classification
- Carotenoid, Xanthophyll
01
Overview
Macular pigment (MP) refers to the carotenoids lutein, zeaxanthin, and meso-zeaxanthin, which are concentrated in the central retina (macula). These pigments filter blue light and act as antioxidants, protecting photoreceptors from photooxidative damage. Low MP levels are associated with increased risk for age-related macular degeneration (AMD).
- Other names
- LuteinZeaxanthinMeso-ZeaxanthinXanthophyll Carotenoids
02
Mechanism of action
Absorption of blue light; Neutralization of reactive oxygen species.
03
Biological functions
Blue light filtrationAntioxidant activityProtection of photoreceptorsVisual performance optimization
04
Disease associations
Age-related Macular Degeneration (AMD)Vision LossOxidative Stress-related diseases
05
Safety considerations
Potential for carotenoidemia (yellowing of the skin) with excessive supplementation.Interactions with other medications or supplements are possible but not well-documented.
06
Interacting drugs
Lutein supplements
2 more in the full profile.
07
Biomarkers
Macular Pigment Optical Density (MPOD)Serum Lutein levelsSerum Zeaxanthin levelsSerum Meso-Zeaxanthin levels
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