Maestro heat-like repeat-containing protein family member 1 (MROH1)

Maestro heat-like repeat-containing protein family member 1 (MROH1) is a large, highly conserved protein characterized by multiple HEAT repeats, which are structural motifs involved in protein-protein interactions and scaffolding[1][2]. MROH1 localizes to the lysosomal membrane, where it is essential for the fission and remodeling of lysosomes[1][3]. It appears to act as an effector for small G-proteins such as RAB7 and is involved in the process of lysosomal membrane severing and vesicle trafficking, likely operating as a membrane scaffold and facilitator of membrane scission[1][2][3]. The protein's activity is important for normal lysosome function, cellular exocytosis, and maintenance of vesicular trafficking; loss of MROH1 function impairs lysosome fission, affects their acidity, and disrupts proteolytic activity, but there is currently no direct evidence supporting its role as a therapeutic target or implication in specific human diseases[1][2][3].

Other names

HEATR7AKIAA1833Maestro heat-like repeat family member 1Maestro heat-like repeat-containing protein family member 1HEAT repeat-containing protein 7AHEAT repeat containing 7A