Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Maestro heat-like repeat family member 6 (MROH6)
- Target
- MROH6
- Molecular classification
- Other (contains HEAT repeat domains; not classified as receptor, enzyme, transporter, or transcription factor)
01
Overview
Maestro heat-like repeat family member 6 (MROH6) is a human protein of 719 amino acids, encoded by the MROH6 gene at chromosome 8q24.3. It contains seven HEAT repeat motifs, structural domains typically facilitating protein-protein interactions. MROH6 is widely expressed in human tissues, with relatively higher levels in esophagus, fetal digestive system, cerebellum, bone marrow, and skin. Although its biological function is not fully established, MROH6 interacts with an array of proteins and is implicated in genetic stability and telomere maintenance, partially due to its interactions and phosphorylation sites. Clinically, increased MROH6 expression is associated with poor prognosis in neuroblastoma, and possibly involved in other conditions such as male infertility and gestational diabetes. There are currently no known drugs that target MROH6, and it is not considered a standard therapeutic target, but it may serve as a biomarker in some cancer contexts.
- Other names
- C8orf73Maestro heat-like repeat-containing protein family member 6
02
Biological functions
Potential involvement in genetic stability maintenanceBroad tissue expression, cytoplasmic/nuclear/mitochondrial localizationPredicted functional roles through protein-protein interactions with various partners
03
Disease associations
Cancer (especially neuroblastoma, with association to poor prognosis on high expression)Male infertility (as a possible contributor, based on expression changes)Other (gestational diabetes, changes in interleukin-18 levels)
04
Biomarkers
High expression as negative prognosis biomarker in aggressive neuroblastoma
Beyond the preview
Go deeper on Maestro heat-like repeat family member 6 (MROH6).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Maestro heat-like repeat family member 6 (MROH6).