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Target intelligence / Profile preview
Maestro heat-like repeat family member 8 (MROH8)
- Target
- MROH8
- Molecular classification
- Other (belongs to the "maestro heat-like repeat-containing" protein family, but not classified under well-established therapeutic target classes such as receptor, enzyme, transporter, channel, etc.)
01
Overview
Maestro heat-like repeat family member 8 is a protein encoded by the MROH8 gene in humans. It belongs to the maestro heat-like repeat family, but its exact biological function is not known. The gene has been identified in genome-wide association studies as being associated with hippocampal atrophy in Alzheimer's disease and has alternative spliced transcript variants encoding different isoforms. It is not currently considered a therapeutic target as there is no evidence of drug interaction or a defined functional role in key biological processes or disease mechanisms.
- Other names
- C20orf131C20orf132dJ621N11.3dJ621N11.4hypothetical protein LOC140699Maestro heat-like repeat-containing protein family member 8protein MROH8
02
Biological functions
Unknown (some evidence for "binding" function per Gene Ontology annotation, but no detailed function described)
03
Disease associations
Alzheimer's disease (based on a genome-wide association study for hippocampal atrophy)Macular dystrophy, retinal, 4Tn polyagglutination syndrome
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