Target intelligence / Profile preview

MAGE family member A8 (MAGEA8)

Target: MAGEA8
Molecular classification: Cancer/Testis Antigen

Overview

MAGEA8 is a member of the MAGEA gene family, typically expressed in various tumors but with limited expression in most normal adult tissues except for testis and placenta. Its precise biological function remains incompletely understood but is implicated in cell cycle regulation and apoptosis resistance. Due to its tumor-restricted expression, it is being explored as a target for cancer immunotherapy.

Other names: Melanoma antigen family a, 8MAGE-8 AntigenCancer/Testis Antigen 1.8 (CT1.8)Cancer/Testis Antigen Family 1, Member 8

Mechanism of action

Peptide vaccines, Adoptive T-cell therapies (in development)

Biological functions

Cell cycle regulation (implicated)Apoptosis resistance (implicated)

Disease associations

CancerMelanomaBenign peritoneal mesothelioma

Safety considerations

Potential for off-target effects in normal tissues expressing MAGEA8 at low levelsImmune-related adverse events associated with immunotherapy

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