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Target intelligence / Profile preview
MAGE family member C1 (MAGE-C1)
- Target
- MAGE-C1
- Molecular classification
- Cancer/testis antigen, MAGE family protein
01
Overview
MAGE-C1 (Melanoma Antigen Gene Family, C1) is a cancer-testis antigen expressed in various tumors, particularly multiple myeloma, but largely absent from normal tissues except for the testis. It plays a role in promoting tumor cell survival and is a promising target for immune-based therapies. Expression levels may also serve as a prognostic marker in certain cancers.
- Other names
- CT7CT7.1cancer/testis antigen 7.1melanoma antigen family C, 1
02
Mechanism of action
Currently under investigation; likely involves disrupting tumor cell survival pathways and enhancing immunogenicity.
03
Biological functions
Promotes tumor cell survivalAnti-apoptoticImmunogenicity
04
Disease associations
CancerMultiple myeloma
05
Safety considerations
Potential for off-target effects due to expression in testisImmune-related adverse events in immunotherapy approaches
06
Biomarkers
MAGE-C1 expression level in tumor tissue
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