Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
MAGE family member C2 (MAGEC2)
- Target
- MAGEC2
- Molecular classification
- Cancer/testis antigen, Protein-coding gene
01
Overview
MAGEC2 is a cancer/testis antigen expressed in various tumors but minimally in normal tissues (except testis). Its expression is linked to oncogenic activation and poor prognosis, making it an attractive target for cancer immunotherapy, particularly TCR-based therapies. It is involved in tumorigenesis by interfering with tumor suppressor pathways.
- Other names
- CT10HCA587MAGEE1Melanoma-associated antigen C2
02
Mechanism of action
TCR gene therapy targeting specific epitopes
03
Biological functions
OncogenesisRegulation of p53 transactivationInteraction with TRIM28Immune response
04
Disease associations
CancerMelanomaHepatocellular carcinomaHead and neck squamous cell carcinoma
05
Safety considerations
Potential for off-target effects in normal tissues expressing MAGE family membersRisk of autoimmunity due to T-cell cross-reactivity
06
Biomarkers
MAGEC2 expression in tumorsALK(336–344)/HLA-A2LLF(191–200)/HLA-A2SES(307–315)/HLA-B44
Beyond the preview
Go deeper on MAGE family member C2 (MAGEC2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on MAGE family member C2 (MAGEC2).