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MAGEA1 Peptide Presented by MHC Class I (MAGEA1-MHC I)

Target: MAGEA1-MHC I
Molecular classification: Receptor (as part of MHC class I antigen presentation), Other (peptide-MHC complex)

Overview

The MAGEA1 peptide presented by MHC class I is a cancer-associated antigen-presenting complex. MAGEA1 is a melanoma-associated antigen primarily expressed in cancer cells and testis tissue. It is recognized by T cells or antibodies that target the MAGEA1 peptide-MHC class I complex, making it a therapeutic target for cancer immunotherapy, particularly in melanoma and other cancers expressing MAGEA1.

Other names: MAGEA1-MHC I complexMAGEA1 peptide-MHC class I complex

Mechanism of action

Targeting cancer cells by recognizing the MAGEA1 peptide presented by MHC class I; Enhancing immune response through TCR or antibody binding

Biological functions

Immune responseAntigen presentationCell recognition

Disease associations

Cancer (specifically melanoma, brain, breast, and other cancers)

Safety considerations

Potential off-target effects due to low specificity of some TCRs or antibodiesLimited expression of MAGEA1 on normal tissues but potential for cross-reactivity

Interacting drugs

Antibodies targeting MAGEA1-MHC I complex (e.g., Fab-G8)

1 more in the full profile.

Biomarkers

MAGEA1 expression in cancer cells

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