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Target intelligence / Profile preview
MAGEA4 antisense RNA 1 (MAGEA4-AS1)
- Target
- MAGEA4-AS1
- Molecular classification
- Long non-coding RNA, Other
01
Overview
MAGEA4 antisense RNA 1 (MAGEA4-AS1) is a long non-coding RNA transcript of approximately 418 nucleotides, found predominantly in the cell nucleus. It is upregulated in oral squamous cell carcinoma (OSCC) tissues compared to normal controls, and its increased expression is associated with enhanced proliferation, migration, and invasion of OSCC cells. Mechanistically, MAGEA4-AS1 interacts with the tumor suppressor protein p53 and enhances p53’s activation of the MK2 gene, thereby promoting downstream signaling pathways that facilitate tumor growth and metastasis. Functional studies indicate that knockdown of MAGEA4-AS1 diminishes these tumor cell behaviors, supporting its evaluation as both a biomarker for OSCC and a candidate therapeutic target.
- Other names
- MAGEA4-AS1
02
Mechanism of action
Molecular mechanism involves binding to p53, which in turn activates MK2 transcription, promoting tumor proliferation and metastasis.
03
Biological functions
Cell proliferationCell migrationCell invasionSignal transduction modulation (via p53/MK2 pathway)Other
04
Disease associations
CancerDysregulated in tumors, specifically OSCC
05
Safety considerations
Not specifically described in available sources; as with other lncRNA targets, potential off-target effects or unanticipated biological roles are general concerns.
06
Biomarkers
MAGEA4-AS1 (diagnostic and prognostic marker for OSCC)
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