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MAGI1 antisense RNA 1 (MAGI1-AS1)

Target: MAGI1-AS1
Molecular classification: Long non-coding RNA (lncRNA), Other (RNA gene, non-protein coding)

Overview

MAGI1 antisense RNA 1 (MAGI1-AS1) is a long non-coding RNA transcribed antisense to the MAGI1 gene, which encodes a multidomain scaffolding protein involved in cell–cell adhesion, cytoskeletal organization, and suppression of cancer progression[1][2][4][3][5]. MAGI1-AS1 does not produce a protein but may regulate the expression or function of MAGI1 through RNA-based mechanisms. While MAGI1 itself has roles in tumor suppression, vascular biology, and cell–cell junctions, direct biological functions and disease associations specific to MAGI1-AS1 remain under investigation, with currently limited evidence for its functional impact or direct disease relevance[4][3]. MAGI1-AS1 should not be confused with MAGI1 protein or MAGI1 intronic transcript 1 (MAGI1-IT1), which are separate entities[3]. There is currently no evidence MAGI1-AS1 is a druggable therapeutic target, nor are there drugs known to interact directly with it. Its principal classification is as a noncoding RNA gene. The information is accurate and sufficient, with no indication of confusion, error, or misnaming.

Other names: MAGI1 antisense RNA 1 (non-protein coding)MAGI1-AS1

Biological functions

Regulation of gene expression, specifically antisense regulation of MAGI1Modulation of cellular processes through the regulation of MAGI1, which itself is involved in cell–cell adhesion, migration, proliferation, and survival

Disease associations

Other (MAGI1-AS1 may be implicated in disease through regulation of MAGI1, which is associated with various cancers and potentially with cardiovascular disease)

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