Magnesium acetyltaurate (MgAT)

Magnesium acetyltaurate (MgAT) is a chelated magnesium salt consisting of magnesium bound to N-acetyltaurine, specifically designed to enhance the bioavailability and lipophilicity of magnesium for targeted delivery to the central nervous system [1, 7]. Unlike standard inorganic magnesium salts, its acetylated structure allows it to cross the blood-brain barrier more efficiently, where it dissociates into magnesium and taurine derivatives [2, 8]. The magnesium component acts as a natural, voltage-dependent blocker of the N-methyl-D-aspartate (NMDA) receptor, preventing the excessive calcium influx that leads to neuronal excitotoxicity and cell death [5, 6]. Simultaneously, the taurine component modulates GABAergic signaling and provides antioxidant protection by reducing nitrosative stress and inhibiting inducible nitric oxide synthase (iNOS) [5, 8]. This dual-action mechanism makes it a potent neuroprotective agent, particularly effective in managing conditions characterized by neuronal hyperexcitability, such as migraines, anxiety, and traumatic brain injury [9]. Additionally, it has been shown to support cardiovascular health and mitigate symptoms of premenstrual syndrome by stabilizing cellular membranes and regulating electrolyte balance [3, 10].

Other names

Magnesium N-acetyltaurinateATA MgMagnesium acetyl taurateMagnesium N-acetyl taurinate

Magnesium acetyltaurate acts as a highly bioavailable source of magnesium and taurine in the brain [1, 2]. Magnesium provides a voltage-dependent block of the NMDA receptor pore, preventing excessive calcium influx and subsequent excitotoxicity [5, 9]. The acetyltaurine component enhances cellular uptake and provides synergistic neuroprotective effects by modulating GABA receptors and reducing the production of reactive oxygen and nitrogen species [4, 8].