Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Magnesium-dependent phosphatase 1 (MDP1)
- Target
- MDP1
- Molecular classification
- Enzyme, Haloacid dehalogenase (HAD) superfamily, Protein tyrosine phosphatase (putative/atypical)
01
Overview
Magnesium-dependent phosphatase 1 (MDP1) is a eukaryotic magnesium-dependent acid phosphatase and an atypical member of the haloacid dehalogenase (HAD) superfamily[1][2][3][4][6]. It preferentially dephosphorylates phosphotyrosine residues, although it can also act on certain phosphosugar substrates such as ribose-5-phosphate and fructosamine-6-phosphate[4][5][6]. Unlike canonical protein tyrosine phosphatases, MDP1 shows low sequence homology with other known phosphatase families, and its structure lacks a "cap" domain typically present in related enzymes, resulting in an "open" active site suitable for large substrates[1][2][3]. MDP1 is not a major established drug target and is not directly linked to common diseases, but it may play a role in cellular phosphate homeostasis and glycation repair. The enzyme is magnesium-dependent and is inhibited by vanadate and fluoride, but not by other common phosphatase inhibitors[4][5][6].
- Other names
- MDP-1MGC5987FN6Pasefructosamine-6-phosphataseFN6PASEmagnesium dependent phosphatase 1
02
Biological functions
Protein dephosphorylationHydrolysis of phosphotyrosine residuesMay act on fructosamine-6-phosphate (glycation repair)
03
Disease associations
Other (no direct, well-established links to major indications such as cancer, neurodegeneration, or cardiovascular disease in current literature)
Beyond the preview
Go deeper on Magnesium-dependent phosphatase 1 (MDP1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Magnesium-dependent phosphatase 1 (MDP1).