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Target intelligence / Profile preview
Magnesium transporter NIPA2 (NIPA2)
- Target
- NIPA2
- Molecular classification
- Transporter, Ion channel (specifically, magnesium transporter), Cation transport protein
01
Overview
Magnesium transporter NIPA2 (NIPA2) is a multi-pass membrane protein highly selective for magnesium ions (Mg2+), with eight predicted transmembrane regions. It is found in many tissues with strong expression in renal cells, where it plays a crucial role in magnesium metabolism and renal magnesium conservation. NIPA2 is localized primarily to early endosomes and the plasma membrane, with relocalization to the cell membrane upon low extracellular magnesium. Mutations or disruption of NIPA2 may be related to genetic disorders involving the Prader-Willi/Angelman syndrome chromosomal region[1][2][3][4].
- Other names
- NIPA magnesium transporter 2SLC57A2Non-imprinted in Prader-Willi/Angelman syndrome region protein 2non imprinted in Prader-Willi/Angelman syndrome 2magnesium transporter NIPA2
02
Mechanism of action
Facilitates selective, electrogenic, and voltage-dependent uptake of Mg2+ ions across cellular membranes[1][2][4]
03
Biological functions
Magnesium ion transportRegulation of magnesium homeostasisRenal magnesium conservation
04
Disease associations
Neurodevelopmental disorders (due to its location in the Prader-Willi/Angelman syndrome region)Genetic syndromes associated with defective magnesium transportOther (renal magnesium handling disorders)
05
Safety considerations
Loss-of-function or mutations may contribute to altered magnesium homeostasis and may be implicated in genetic or renal disorders, but no specific therapeutic safety concerns are established[1][3]
06
Interacting drugs
None known
07
Biomarkers
None established
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