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Magnetic Resonance Imaging Signal Alteration via Local Field Inhomogeneity Induced by Superparamagnetic Iron Oxide Core
- Molecular classification
- Nanoparticle, Inorganic compound (Iron Oxide), Contrast agent
01
Overview
Superparamagnetic iron oxide nanoparticles (SPIONs) are used as MRI contrast agents. They create local magnetic field inhomogeneities, which accelerate the dephasing of proton spins in surrounding water molecules. This leads to a reduction in T2 and T2* relaxation times, resulting in hypointense signals (darkening) on T2-weighted MRI images. SPIONs are used in applications such as tumor detection, cell tracking, and vascular imaging.
- Other names
- SPION MRI contrastSuperparamagnetic iron oxide nanoparticle MRI contrastSPIO-induced MRI signal alterationLocal field inhomogeneity MRI contrast
02
Mechanism of action
Induction of local magnetic field inhomogeneities that accelerate the dephasing of water proton spins, leading to decreased T2/T2* MRI signal intensity.
03
Biological functions
MRI contrast enhancementLocal magnetic field disruptionAcceleration of proton dephasing
04
Disease associations
Tumor imagingInflammation detectionVascular imagingBlood-brain barrier assessmentCell tracking
05
Safety considerations
Potential for iron overloadHypersensitivity reactionsEffects on reticuloendothelial systemNephrogenic Systemic Fibrosis (less risk compared to Gadolinium)
06
Interacting drugs
Ferumoxytol
3 more in the full profile.
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