MAGUK p55 scaffold protein 2 (MPP2)

MAGUK p55 scaffold protein 2 (MPP2) is a postsynaptic scaffold protein of the membrane-associated guanylate kinase (MAGUK) family, found in the postsynaptic density (PSD) of glutamatergic neurons[1][4][5][8]. MPP2 links cell adhesion molecules, such as SynCAM1, with core proteins and receptor complexes at excitatory synapses, including AMPA and GABA(A) receptors[1][4][8]. It is thought to regulate synaptic protein complex formation, organize postsynaptic signaling, and interact with cytoskeletal elements[3][5][4][8]. Unlike classical enzymes, receptors, or ion channels, MPP2 does not have known direct ligand or drug binding activity and is not recognized as a direct therapeutic target. Variants in MPP2 may contribute to susceptibility to vascular and autoimmune disorders involving the blood-retina barrier[10]. Notes and explanation: - **is_incorrect:** true — "MPP2" is not a classical therapeutic target such as a receptor, enzyme, transporter, ion channel, etc.; it is a scaffold protein in synaptic organization[1][4][5][8]. - **Aliases:** These include alternative names referenced in authoritative databases and literature[5][9]. - **Interacting drugs, mechanism_of_action, biomarkers, safety_concerns:** No evidence of drugs directly targeting MPP2, nor of clinical biomarker or safety profile information, as it is not a direct pharmacological target. - **Disease roles:** Some recent evidence links MPP2 mutations to retinal vascular and autoimmune disorders[10]. Ambiguity note: There is a minor ambiguity, as "MPP2" could also refer to "M-phase phosphoprotein 2" (a different protein), or to multipotent progenitor 2 (a hematopoietic cell type)[6][7]. However, nearly all references and context here indicate the synaptic scaffold protein. If you require structured information for another MPP2 entity, please clarify.

Other names

Membrane palmitoylated protein 2Palmitoylated membrane protein 2MAGUK p55 subfamily member 2