MAGUK p55 scaffold protein 4 (MPP4)

MAGUK p55 scaffold protein 4 (MPP4) is a scaffold protein belonging to the membrane-associated guanylate kinase (MAGUK) family, characterized by the presence of PDZ, SH3, and GUK domains[1][3][6]. MPP4 is primarily expressed in the retina, especially at the outer limiting membrane, where it organizes specialized intercellular junctions and helps establish photoreceptor polarity, thought to be critical for retinal cell architecture and function[1][6]. Mutations or dysfunctions in MPP4 have been associated with retinal disorders such as strabismus and retinitis pigmentosa[1][5]. MPP4 is not characterized as a direct therapeutic target and currently has no known drug interactions, biomarker usage, or safety concerns relevant for pharmacology[1][5][6].

Other names

MAGUK p55 subfamily member 4MPP4ALS2CR5DLG6Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 proteinDiscs large homolog 6Membrane palmitoylated protein 4Membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)