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Major Basic Protein 1 (eMBP1)
- Target
- eMBP1
- Molecular classification
- Protein, Cytotoxin, C-type lectin-like domain containing protein
01
Overview
Major basic protein 1 (MBP1), also known as eosinophil granule major basic protein 1, is a highly cationic protein predominantly found in the crystalline core of eosinophil granules. It plays a central role in host defense against parasitic infections and contributes to immune hypersensitivity reactions. MBP1 acts as a cytotoxin and helminthotoxin, damaging epithelial cells and inducing inflammation. It is implicated in allergic diseases like asthma and is found at high levels in placenta/pregnancy serum.
- Other names
- PRG2BMPGMBPproteoglycan 2 (proMBP)bone marrow NK cell activator
02
Mechanism of action
Direct cytotoxicity toward target cells; induction of inflammation
03
Biological functions
Host defense against parasitic infectionsCytotoxicityHelminthotoxicityMediator of allergic inflammationHistamine releaseNeutrophil activationMacrophage activationBronchospasm induction
04
Disease associations
Allergic diseasesAsthmaParasitic infectionsAtopic conditionsInflammatory conditions
05
Safety considerations
Epithelial damageAirway hyperresponsivenessPotential for off-target cytotoxicity
06
Biomarkers
Elevated eMBP1 levels correlate with disease severity in allergic and inflammatory conditions
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