Major capsid protein L1, Human papillomavirus type 6 (L1)

The major capsid protein L1 of Human papillomavirus type 6 is the principal structural protein forming the viral capsid, assembling into 72 pentamers that create an icosahedral structure approximately 50 nm in diameter[5][6]. L1 is essential for viral infectivity; it mediates attachment to host cells and encapsidates the ~8 kb HPV genome[1][3]. Recombinant L1 can self-assemble into highly immunogenic virus-like particles, which underlie current prophylactic HPV vaccines[3]. Neutralizing antibodies targeting specific surface loops of L1 can prevent infection by inhibiting virus attachment or entry into host cells[4]. HPV6 L1 is the immune focus in preventing diseases like genital warts and respiratory papillomatosis caused by HPV6 infection.

Other names

HPV-6 L1 proteinL1 proteinHPV6 L1

Induction of neutralizing antibodies that prevent viral attachment and entry; vaccines use L1 virus-like particles to stimulate immunity