Major facilitator superfamily domain-containing protein 6 (MFSD6)

Major facilitator superfamily domain-containing protein 6 (MFSD6) is a transmembrane protein predicted to function as a transporter within the major facilitator superfamily (MFS) and to act as an atypical solute carrier (SLC) in human cells[1][3]. MFSD6 features twelve predicted transmembrane segments and is most abundantly expressed in neurons, especially in the brain, but it is also expressed in both central and peripheral tissues in mouse models[1]. Immunohistological studies show its localization is cytosolic and not associated with lysosomes, distinguishing it from the related transporter MFSD8[1]. Phylogenetically, MFSD6 is closely related to MFSD8 and MFSD10, proteins that are associated with diseases such as neurodegeneration and drug resistance, respectively[1]. MFSD6 is predicted to bind MHC class I molecules and may play a role in antigen processing and presentation, making it potentially relevant for immune system processes[3]. Expression studies imply that MFSD6 could be involved in energy homeostasis, with its brain expression responding to changes in energy intake in vivo[1]. The specific endogenous substrate and therapeutic relevance of MFSD6 remain unknown, and there are no approved drugs explicitly targeting this protein as of September 2025. **Note:** - There is another related protein, MFSD6L ("MFSD6-like"), but it is a distinct gene product and should not be conflated with MFSD6[2][3]. - No established clinical biomarkers, safety concerns, or direct drug interactions have been reported for MFSD6 as of the current literature.

Other names

MMR2SLC73A1FLJ20160macrophage MHC class I receptor 2 homologhMMR2macrophage MHC receptor 2