major histocompatibility complex, class II, DP beta 2 (pseudogene) (HLA-DPB2)

HLA-DPB2 is a human pseudogene related to the class II beta chain locus, HLA-DPB1. While HLA-DPB1 encodes the beta chain of the HLA-DP molecule—a cell-surface receptor critical in adaptive immune responses—HLA-DPB2 does not encode a protein product. HLA-DPB2 modulates immune regulation by acting at the RNA level to upregulate its parent gene, HLA-DPB1. It is significantly overexpressed in breast cancer tissues, correlating with enhanced immune cell infiltration and improved prognosis, but is not itself a protein receptor or enzyme. The functional axis between HLA-DPB2 (pseudogene RNA) and HLA-DPB1 (antigen presentation) is relevant to tumor biology and as a prognostic biomarker. However, HLA-DPB2 is not a conventional drug target and should not be mistaken for the protein-coding immune receptor HLA-DPB1.

Other names

HLA-DPB2DPB2DP2BDPbeta2HLA-DP2B

HLA-DPB2 participates in a competitive endogenous RNA (ceRNA) mechanism, ‘sponging’ microRNAs such as has-miR-370-3p, thereby upregulating HLA-DPB1 expression, which is implicated in antitumor immune responses and improved immunotherapy efficacy.