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Target intelligence / Profile preview
Major Histocompatibility Complex Class I-Related Protein B (MICB)
- Target
- MICB
- Molecular classification
- MHC Class I-related protein, Receptor Ligand
01
Overview
MICB is a stress-induced ligand structurally related to MHC class I molecules. It binds to the activating receptor NKG2D on NK cells and some T cells, triggering immune responses against cells experiencing stress, such as those infected with viruses or undergoing transformation.
02
Mechanism of action
NKG2D receptor activation leading to NK cell-mediated cytotoxicity
03
Biological functions
Immune activationStress surveillanceNK cell activation
04
Disease associations
CancerInfectionAutoimmunity (potential)
05
Safety considerations
Potential for off-target NK cell activationShedding of soluble MICB leading to immune evasion
06
Biomarkers
MICB expression levels in tumorsSoluble MICB levels in serum
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