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Major histocompatibility complex class II DQ alpha 2 (None)
- Target
- None
- Molecular classification
- MHC class II alpha chain
01
Overview
The major histocompatibility complex class II DQ alpha 2 (HLA-DQA2) is a protein that plays a central role in immune function. It forms a heterodimer with an MHC class II beta chain and is involved in peptide loading and antigen presentation to CD4+ T-cells. While it participates in MHC class II function, it exhibits lower expression than its paralog HLA-DQA1 due to impaired promoter activity. Genetic variations near HLA-DQA2 are associated with Crohn's disease, narcolepsy, and certain cancers. Heightened expression may correlate with reduced susceptibility to COVID-19 infection.
- Other names
- HLA-DQA2HLA-DXADAAP-381D23.2
02
Mechanism of action
N/A
03
Biological functions
Antigen processingImmune responsePeptide loadingAntigen presentation
04
Disease associations
Crohn's diseaseNarcolepsyPenile carcinoma in situCOVID-19 (reduced susceptibility)
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