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Target intelligence / Profile preview
Major Homology Region of Capsid Protein (MHR)
- Target
- MHR
- Molecular classification
- Protein Domain, Viral Protein
01
Overview
The major homology region (MHR) is a highly conserved stretch of approximately 20 amino acids within the capsid (CA) domain of the Gag polyprotein in all orthoretroviruses and some retrotransposons. It is essential for proper formation and maturation of the viral capsid shell, which encases the viral replication complex. The MHR plays a crucial role in viral assembly and infectivity, contributing significantly to overall capsid structure and stability. Mutations within this region disrupt membrane binding affinity, impair particle assembly, block infectivity, or result in non-infectious particles.
02
Mechanism of action
Disruption of capsid assembly/maturation
03
Biological functions
Viral assemblyCapsid formationMembrane bindingViral infectivity
04
Disease associations
Infection
05
Safety considerations
Potential for drug resistance mutationsOff-target effects on host proteins
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