Major house dust mite allergen (Der p 1, Der p 2, Der p 23) (Der p 1, Der p 2, Der p 23)

Major house dust mite allergens are a group of proteins derived primarily from *Dermatophagoides pteronyssinus* that are recognized by the immune system of allergic patients, with Der p 1 (cysteine protease), Der p 2 (lipid-binding protein homologous to NPC2 and MD-2), and Der p 23 (peritrophin-like chitin-binding protein) being the most clinically important[1][5][3]. These allergens are responsible for the majority of IgE reactivity in house dust mite-allergic individuals and are major triggers for asthma, rhinitis, and atopic eczema. They are used as major molecular components in allergy diagnostics and specific immunotherapy, and they interact directly and indirectly with immune pathways, including protease activity (Der p 1), lipid/cholesterol binding (Der p 2), and innate immune recognition.

Other names

House dust mite major allergensHDM major allergensGroup 1/2/23 allergensDermatophagoides pteronyssinus major allergensDer p major allergens

Induction of IgE-mediated hypersensitivity; Activation of basophils and mast cells; Upregulation of immune activation markers (e.g., CD203c by Der p 23); Some (e.g., Der p 2) can mimic or activate TLR4 pathways