Major intrinsically disordered Notch2-binding receptor 1 (MINAR1)

Major intrinsically disordered Notch2-binding receptor 1 (MINAR1) is a single-pass cell surface receptor and an **intrinsically disordered protein** with roughly 70% of its sequence unstructured, encoded by the human gene KIAA1024. MINAR1 physically interacts with the Notch2 receptor, increasing its stability and function, and is widely expressed in various tissues, including breast epithelium and vascular endothelium[1][2][4][5]. It inhibits angiogenesis and proliferation of breast cancer cells, with its expression reduced in advanced breast cancer, suggesting a tumor suppressor-like function. Moreover, MINAR1 is proposed to **negatively regulate the mTOR signaling pathway** via stabilization of the mTOR complex component DEPTOR, and may play broader roles in signaling networks by virtue of its disordered structure and protein–protein interactions[1][2][3][4][5]. No drugs are currently reported to directly target MINAR1, and its precise clinical targeting implications remain under investigation.

Other names

Membrane integral NOTCH2-associated receptor 1MINAR1KIAA1024UBTORUbiquitination and mTOR signaling protein