Makorin ring finger protein 1 pseudogene

The makorin ring finger protein 1 pseudogene (ENSG00000234932) is a genomic DNA segment closely resembling the functional MKRN1 gene, which encodes an E3 ubiquitin ligase involved in transcriptional regulation and protein degradation. As a pseudogene, ENSG00000234932 is nonfunctional—it does not encode a protein or exert direct physiological effects. Pseudogenes typically arise from gene duplication or retrotransposition and accumulate disabling mutations. While some pseudogenes have regulatory effects on their parent gene, most—including MKRN1 pseudogenes—are considered genomic “fossils” with limited or no biological activity. The canonical MKRN1 gene is involved in cell cycle, apoptosis, and disease regulation, but its pseudogenes are not actionable drug targets and do not play a direct role in cellular pathways. ENSG00000234932 is a nonfunctional pseudogene derived from the MKRN1 gene. It is not a protein, receptor, nor a therapeutic target. The canonical target in this biological family is makorin ring finger protein 1 (MKRN1), an E3 ubiquitin ligase involved in cell cycle and transcriptional regulation.

Other names

Makorin ring finger protein 1 pseudogeneMKRN1 pseudogeneAlias may vary by chromosomal location

Not applicable