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Malaria protein Exported Protein 1 (EXP1)

Target: EXP1
Molecular classification: Membrane protein, Enzyme, Glutathione S-transferase

Overview

Malaria protein EXP1 (Exported Protein 1) is a single-pass integral membrane protein found in Plasmodium falciparum. It localizes to the parasitophorous vacuole membrane (PVM) and plays an essential role in nutrient uptake and membrane organization, supporting intraerythrocytic development of malaria parasites. EXP1 possesses an in vitro glutathione S-transferase (GST) activity, though this enzymatic function does not appear to be essential for its critical role in vivo. It interacts with other PVM proteins, such as EXP2, to maintain proper organization within the PVM compartment.

Mechanism of action

Unknown

Biological functions

Nutrient uptakeMembrane organizationVacuole structure maintenance

Disease associations

Infection

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