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Target intelligence / Profile preview
Malate Dehydrogenase (MDH)
- Target
- MDH
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Malate dehydrogenase (MDH) is a ubiquitous enzyme found in all domains of life, playing a central role in cellular metabolism. It catalyzes the reversible conversion of L-malate to oxaloacetate, using NAD+ (or sometimes NADP+) as a cofactor. This reaction is crucial for the citric acid cycle and other metabolic pathways. In eukaryotes, it exists as two main isoforms: Mitochondrial MDH (m-MDH) and Cytosolic MDH (c-MDH or s-MDH). MDHs are being explored as therapeutic targets, and inhibitors are under investigation as both broad-spectrum agents and isoform-selective drugs.
02
Mechanism of action
Inhibition of Malate Dehydrogenase
03
Biological functions
Citric acid cycleMalate-aspartate shuttleCellular metabolism
04
Disease associations
CancerInfectious DiseasesTissue Damage (Diagnostic marker)
05
Biomarkers
Elevated serum or cerebrospinal fluid levels (diagnostic)
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