Target intelligence / Profile preview

Malate Dehydrogenase (MDH)

Target: MDH
Molecular classification: Enzyme, Oxidoreductase

Overview

Malate dehydrogenase (MDH) is a ubiquitous enzyme found in all domains of life, playing a central role in cellular metabolism. It catalyzes the reversible conversion of L-malate to oxaloacetate, using NAD+ (or sometimes NADP+) as a cofactor. This reaction is crucial for the citric acid cycle and other metabolic pathways. In eukaryotes, it exists as two main isoforms: Mitochondrial MDH (m-MDH) and Cytosolic MDH (c-MDH or s-MDH). MDHs are being explored as therapeutic targets, and inhibitors are under investigation as both broad-spectrum agents and isoform-selective drugs.

Mechanism of action

Inhibition of Malate Dehydrogenase

Biological functions

Citric acid cycleMalate-aspartate shuttleCellular metabolism

Disease associations

CancerInfectious DiseasesTissue Damage (Diagnostic marker)

Biomarkers

Elevated serum or cerebrospinal fluid levels (diagnostic)

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