Malignant mesothelioma cell (null)

Malignant mesothelioma cells are cancerous, typically arising from the mesothelial lining of the pleura, peritoneum, or other serosal surfaces. These cells are characterized by extensive heterogeneity in chromosomal structure, epigenetic regulation, and molecular signaling. Key molecular features include frequent inactivation or dysregulation of tumor suppressors (e.g., BAP1, CDKN2A, NF2), aberrant activation of oncogenic pathways (RAS/MAPK, Hedgehog, PI3K/mTOR), and variable status of biomarkers such as calretinin. Malignant mesothelioma is strongly associated with asbestos exposure and is difficult to treat due to complex biology, molecular diversity, and drug resistance

Other names

Malignant pleural mesothelioma cellmesothelioma cellMM cellMPM cell

Inhibition of signal transduction pathways (e.g., MAPK, Hedgehog, mTOR) Induction of cell cycle arrest and apoptosis Inhibition of migration and EMT Cytotoxicity via DNA damage