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Maltase-Glucoamylase (None)
- Target
- None
- Molecular classification
- Enzyme, Glycoside hydrolase family 31 (GH31)
01
Overview
Maltase-glucoamylase (MGAM) is a membrane-bound alpha-glucosidase enzyme located in the brush border of the small intestine. It plays a critical role in the final steps of dietary starch digestion, hydrolyzing linear regions of starch and maltose into glucose for absorption. MGAM works synergistically with other enzymes such as sucrase-isomaltase and alpha-amylase to ensure efficient breakdown of complex carbohydrates. Inhibitors targeting MGAM—such as miglitol—are used therapeutically for managing postprandial blood glucose levels.
- Other names
- Glucan 1,4-alpha-glycosidase
02
Mechanism of action
Inhibition of intestinal carbohydrate breakdown, reducing postprandial blood glucose levels.
03
Biological functions
Dietary starch digestionHydrolysis of α-(1→4) glycosidic bondsGlucose productionCarbohydrate metabolism
04
Disease associations
Acute diabetic complicationsInborn errors of carbohydrate metabolism
05
Interacting drugs
Miglitol
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