MAMDC2 antisense RNA 1 (MAMDC2-AS1)

MAMDC2 antisense RNA 1 (MAMDC2-AS1), also known as SMC5-DT, is a long non-coding RNA (lncRNA) transcribed from the antisense strand at the MAMDC2 locus on chromosome 9q21.12[1][3][4][5][6]. It does not encode a protein and is not part of canonical receptor, enzyme, or transporter families. Recent research indicates that MAMDC2-AS1 is upregulated in multiple human cell types upon herpes simplex virus 1 (HSV-1) infection and plays a critical regulatory role in the viral life cycle by interacting with Hsp90α, facilitating the nuclear import of viral components and controlling the expression of immediate early viral genes[2][8]. MAMDC2-AS1 knockdown reduces HSV-1 infection and is associated with altered expression of some antiviral factors, though it does not affect its sense gene (MAMDC2) directly[2]. In addition, MAMDC2-AS1 has been linked (mainly through association studies or expression profiling) to colorectal cancer and possibly other diseases, but mechanistic roles in cancer or as a therapeutic target remain unproven[4]. No drugs are known to interact specifically with MAMDC2-AS1, and there are currently no established safety or biomarker roles in clinical practice.

Other names

SMC5-DTSMC5 divergent transcriptMAMDC2-AS1

Not applicable; MAMDC2-AS1 is not a conventional drug target or protein; functions through RNA-protein interactions (notably with Hsp90α) rather than as a biochemical receptor/enzyme