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Target intelligence / Profile preview
Mammaglobin A (MGB1)
- Target
- MGB1
- Molecular classification
- Secretoglobin, Secreted protein
01
Overview
Mammaglobin A (SCGB2A2) is a small, secreted protein highly specific to mammary tissue. It is frequently overexpressed in breast carcinomas and serves as a diagnostic marker for detecting circulating tumor cells or micrometastases. While its exact physiological role is incompletely understood, it is believed to play roles in cell signaling, immune response, chemotaxis, and steroid hormone transport. Recent studies suggest its potential as a therapeutic target for antibody-mediated drug delivery.
- Other names
- Secretoglobin family 2A member 2SCGB2A2UGB2PSBP1
02
Mechanism of action
Antibody-mediated drug delivery (potential)
03
Biological functions
Cell signalingImmune responseChemotaxisSteroid hormone transport
04
Disease associations
Cancer
05
Biomarkers
Breast cancer detectionMicrometastasis detectionCirculating tumor cell detectionEstrogen receptor-positive (ER+) tumors
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