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The mammalian cell membrane, or plasma membrane, is a dynamic lipid bilayer embedded with a diverse array of proteins, carbohydrates, and cholesterol. It is fundamental for protecting cellular contents, mediating communication with the extracellular environment, facilitating selective transport, and maintaining cellular structure[3][5][6][7]. Its composition and function are highly regulated and serve as the foundation for many physiological processes. Disease states frequently involve defects in membrane protein function, repair mechanisms, or lipid composition, but therapies usually target specific membrane components rather than the membrane structure itself[1][4]. In summary: Mammalian cell membrane is not a drug target, but a foundational cell structure supporting specific therapeutic targets (membrane proteins, receptors, channels) which should be named and categorized individually for therapeutic and biomarker purposes.
For membrane proteins: receptor modulation, channel block/activation, transporter inhibition/activation, signal transduction interference, but no direct mechanisms against the "membrane" structure as a whole
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