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Target intelligence / Profile preview
Mammalian Diaphanous-related Formin 1 (mDia1/DRF1)
- Target
- mDia1/DRF1
- Molecular classification
- Formin, Rho GTPase effector protein, Actin regulator, Microtubule regulator, Transcription factor (sometimes)
01
Overview
Mammalian diaphanous-related formin 1 (mDia1/DRF1) is a Rho GTPase effector protein that regulates the actin and microtubule cytoskeletons. It is involved in various cellular processes such as cell migration, cytokinesis, phagocytosis, and vesicle trafficking. Activation occurs upon binding to active Rho-family GTPases, leading to actin polymerization and microtubule stabilization. HIV-1 exploits DRF functions to facilitate virus transport within host cells.
- Other names
- Dia1Drf1Diaphanous-related formin-1KIAA4062p140mDiaDIAPH1
02
Mechanism of action
Upon activation by small GTPases, mDia1 promotes actin polymerization/nucleation at the barbed end of actin filaments and stabilizes microtubules.
03
Biological functions
Actin filament nucleation and elongationMicrotubule stabilizationCell migrationCytokinesisPhagocytosisVesicle traffickingStress fiber formationFilopodia formationCytokinetic ring assemblyCell adhesionCell polarization
04
Disease associations
Infection (HIV-1)Immune defects (impaired chemotaxis/polarity/adherence)
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