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Target intelligence / Profile preview
Mammalian Target Of Rapamycin Complex 2 (mTORC2)
- Target
- mTORC2
- Molecular classification
- Multi-protein complex, Serine/threonine kinase
01
Overview
The mammalian target of rapamycin complex 2 (mTORC2) is a multi-subunit protein kinase complex that plays a central role in regulating cell growth, survival, metabolism, and cytoskeletal organization. It consists of mTOR, Rictor, SIN1, mLST8, and variably associated components like Protor/PRR5/PRR5L and DEPTOR. mTORC2 regulates key cellular processes including cell proliferation, survival, metabolism and actin cytoskeleton organization. Aberrant activation is linked to various cancers making it an important therapeutic target.
- Other names
- MTORC2mTOR complex 2
02
Mechanism of action
Inhibition of mTORC2 kinase activity, although native mTORC2 is acutely insensitive to rapamycin. Prolonged exposure can disrupt assembly and affect function.
03
Biological functions
Cell proliferationCell survivalMetabolismActin cytoskeleton organizationAutophagy regulationInsulin signaling
04
Disease associations
CancerNeurological disorders
05
Safety considerations
Aberrant activation is linked to various cancers.Therapeutic challenges due to rapamycin insensitivity.
06
Interacting drugs
Rapamycin
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