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Target intelligence / Profile preview
Mammalian Target Of Rapamycin Complex I (mTORC1)
- Target
- mTORC1
- Molecular classification
- Multi-protein complex, Kinase complex
01
Overview
The mammalian target of rapamycin complex 1 (mTORC1) is a multi-protein complex that plays a central role in regulating cell growth, proliferation, metabolism, and survival in response to nutrient and energy status, as well as various extracellular signals. mTORC1 is frequently deregulated in human cancers and other diseases.
02
Mechanism of action
Rapamycin binds FKBP12, and the resulting complex interacts with mTORC1, disrupting its structure and function, inhibiting downstream signaling.
03
Biological functions
Regulation of cell growthRegulation of cell proliferationRegulation of metabolismRegulation of survivalProtein biosynthesisLipid biosynthesisNucleotide biosynthesisOrganelle biogenesisTranslation initiationRibosome biogenesismRNA translation elongation
04
Disease associations
CancerMetabolic disordersNeurodegenerative diseases
05
Safety considerations
ImmunosuppressionPotential for compromised structural integrity of mTORC1 with prolonged exposure to inhibitors
06
Interacting drugs
Rapamycin
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