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Manganese cation (Mn²⁺)
- Target
- Mn²⁺
- Molecular classification
- Inorganic ion, Metal cation, Enzyme cofactor
01
Overview
The manganese cation, Mn²⁺ (manganese(II) or manganous ion), is a divalent metal ion essential for various biological processes. It acts as a cofactor for enzymes involved in metabolism, antioxidant defense, bone formation, reproduction, and immune response. It is also used as a paramagnetic contrast agent for MRI. While essential, high concentrations can be toxic due to interference with other metal-dependent processes.
- Other names
- Manganous ionManganese(II)Mn+2Manganese ion(2+)
02
Mechanism of action
Acts as a cofactor for enzymes; Alters local magnetic fields to enhance MRI contrast; Can interfere with other metal-dependent biological processes at high concentrations.
03
Biological functions
Enzyme cofactorAntioxidant defenseBone formationReproductionImmune responseMRI contrast agent
04
Disease associations
Manganese deficiencyNeurotoxicity (excessive levels)Neurological disorders (related to manganese dysregulation)
05
Safety considerations
Neurotoxicity at high concentrationsPotential for interference with other metal-dependent processesRisk of manganese overload during parenteral nutrition
06
Interacting drugs
Chelating agents (e.g., EDTA, deferoxamine)
2 more in the full profile.
07
Biomarkers
Serum manganese levelsManganese levels in brain tissue (MRI)Activity of manganese-dependent enzymes (e.g., superoxide dismutase)
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