Manganese-dependent metalloenzyme

Manganese-dependent metalloenzymes and proteins represent a **broad group of enzymes and proteins requiring manganese as a critical metal cofactor** for their biological activity. This terminology does not correspond to a unique, single molecular target but encompasses many individual enzymes, including oxidoreductases (such as manganese superoxide dismutase), transferases (such as glycosyltransferases), hydrolases (such as arginase), and others[2][4][5][6][8]. These enzymes perform a diverse set of vital biological functions, including **protection against reactive oxygen species (antioxidant defense), metabolism of carbohydrates and amino acids, urea formation, neurotransmitter metabolism, and biosynthesis of cartilage and bone**[2][4][6]. The specific molecular function and disease associations are unique to each manganese-dependent enzyme; for example, manganese superoxide dismutase (MnSOD) is a key mitochondrial antioxidant, while arginase is involved in the urea cycle[2][8]. "**Manganese-dependent metalloenzymes and proteins**" is **not the canonical name of a single target**—rather, it is a functional category describing many structurally and mechanistically diverse proteins[5][6]. For structured database purposes, entries should refer to specific enzyme names (e.g., "Manganese superoxide dismutase", "Arginase", "Glycosyltransferase", etc.) to capture molecular specificity. Key notes: - **is_target: false** (this is a category, not a unique drug target) - **is_incorrect: true** (the entry is too broad/vague; it groups many unrelated proteins. Best practice: specify individual enzyme names.) - **aliases** are mostly descriptive/functional; proper synonyms refer to each specific enzyme. - **molecular_classifications, biological_functions, disease_roles** and other fields are representative summaries, not unique to a single molecule. - **interacting_drugs, mechanism_of_action, biomarkers, safety_concerns** can only be accurately assigned at the level of single enzyme entities. For further structured data and therapeutic or mechanistic detail, identify a specific manganese-dependent metalloenzyme of interest (e.g., "Manganese superoxide dismutase" or "Arginase").

Other names

Manganese-dependent enzymeMn-dependent proteinMnSOD (for "Manganese superoxide dismutase", a specific example)Manganese enzyme

Redox catalysis by cycling between Mn(II)/Mn(III); stabilization of charged intermediates; electron transfer; activation of substrate; most precise mechanisms are enzyme-specific