Manganese ion homeostasis

Manganese ion homeostasis encompasses the physiological processes by which organisms regulate and maintain cellular and systemic levels of manganese ions (Mn²⁺). Manganese is an essential trace element serving as a cofactor for various enzymes involved in metabolism, antioxidant defense (e.g., manganese superoxide dismutase), and cellular regulation. Tight control is critical, as both deficiency and excess can lead to cellular dysfunction and disease. Homeostasis is mediated through a network of transporters (including DMT1, ZIP8, ZIP14, SLC30A10), cation transport ATPases, and regulatory proteins that coordinate absorption, storage, and efflux of manganese. Disruption of these processes can result in neurological disorders, altered susceptibility to infection in pathogens, and other systemic effects[4][5][10]. Summary of issues: "Manganese ion homeostasis" is a process, not a discrete molecule, gene, or receptor. For drug discovery or molecular targeting, one should specify the particular transporter or protein (e.g., "solute carrier family 30 member 10" (SLC30A10), "divalent metal transporter 1" (DMT1), "natural resistance-associated macrophage protein 1" (Nramp1)) involved in manganese ion regulation[4][5][10].

Other names

Regulation of manganese homeostasisManganese homeostasisMn homeostasisManganese ion regulation

Not directly applicable; drugs affecting homeostasis typically function via metal chelation or modulation of transporter activity