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Manganese Transporter C (MntC)
- Target
- MntC
- Molecular classification
- Transporter, ABC Transporter Substrate-Binding Protein
01
Overview
Manganese transporter C (MntC) is a highly conserved cell surface protein in Staphylococcus aureus. It functions as the substrate-binding component of the ATP-binding cassette (ABC) manganese transporter system, MntABC. MntC is crucial for manganese acquisition from the host environment, a process essential for bacterial survival and virulence during infection. It also binds extracellular matrix and coagulation cascade proteins, potentially aiding colonization. Due to its conservation and surface exposure, MntC is a promising vaccine candidate and target for antibody-based therapeutics.
- Other names
- MntC (Staphylococcus aureus)Staphylococcus aureus MntCManganese-binding protein MntCABC manganese transporter MntC
02
Mechanism of action
Inhibition of manganese uptake; Antibody-mediated neutralization; Immune activation
03
Biological functions
Manganese uptakeMetal ion transportHost interactionVirulence
04
Disease associations
InfectionStaphylococcus aureus Infections
05
Safety considerations
Potential for off-target effects if antibodies cross-react with human proteinsDevelopment of resistance
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