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Target intelligence / Profile preview
Manganese Transporter Subunit C (MntC)
- Target
- MntC
- Molecular classification
- Transporter, ABC Transporter, Membrane Protein
01
Overview
Manganese transporter subunit C is an integral membrane protein component of bacterial ABC-type manganese transporter systems, such as MntABCD. It forms the permease channel with subunit D, mediating high-affinity uptake of Mn²⁺ from the environment. This process is critical for bacterial survival in manganese-limited conditions and plays a role in various cellular processes requiring manganese as a cofactor.
- Other names
- MntC subunitManganese ABC transporter subunit CManganese transport protein C
02
Mechanism of action
Not applicable; subunit of a transporter complex. Potential mechanisms involving disrupting the transporter complex.
03
Biological functions
Manganese ion transportMetal ion homeostasisNutrient uptake
04
Disease associations
Infection (bacterial)Oxidative stress related diseasesBiofilm formation (in some bacteria)
05
Safety considerations
Potential for off-target effects on other metal transportersDisruption of manganese homeostasis
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