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Target intelligence / Profile preview
Mannan-binding lectin-associated serine protease 3 (MASP-3)
- Target
- MASP-3
- Molecular classification
- Enzyme, Serine Protease
01
Overview
Mannan-binding lectin-associated serine protease 3 (MASP-3) is a serine protease involved in the lectin and alternative pathways of the complement system. It activates complement factor D, which is crucial for initiating and amplifying the alternative pathway. MASP-3 also plays a role in embryonic development and can inhibit MASP-2 function within MBL-MASP complexes. Mutations in MASP-3 are associated with 3MC syndrome, a rare congenital disorder characterized by craniofacial abnormalities and intellectual disability.
02
Mechanism of action
Inhibition of MASP-3 activity could potentially modulate the alternative pathway of the complement system.
03
Biological functions
Complement activationAlternative pathway amplificationRegulation of complement systemEmbryonic development
04
Disease associations
Developmental disorders3MC syndromeImmune dysregulation
05
Safety considerations
Potential for off-target effects on other serine proteasesDisruption of complement system homeostasisSide effects related to IGFBP5 inhibition
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