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Target intelligence / Profile preview
Mannan-binding lectin serine protease (MASP)
- Target
- MASP
- Molecular classification
- Enzyme, Serine Protease
01
Overview
Mannan-binding lectin serine proteases (MASPs) are a family of enzymes crucial to the activation of the lectin pathway in the complement system. The main members include MASP-1, MASP-2, and MASP-3. These enzymes associate with pattern recognition molecules such as mannose-binding lectin (MBL) and ficolins to recognize pathogen-associated carbohydrate patterns and initiate immune responses. They play a central role in innate immunity and can contribute to both pathogen clearance and inflammatory diseases.
- Other names
- Mannan-binding lectin serine protease 1Mannose-binding lectin-associated serine protease 1Complement factor MASP-3Serine protease 5Ra-reactive factor serine protease p100
02
Mechanism of action
Inhibition of MASP activity
03
Biological functions
Lectin pathway activationComplement system activationInnate immune responseAlternative pathway activationBlood coagulation
04
Disease associations
InfectionAutoimmune diseasesLupus-like glomerulonephritisInflammation
05
Safety considerations
Excessive complement inhibition leading to increased susceptibility to infectionUncontrolled complement activation contributing to autoimmune diseases
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