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Target intelligence / Profile preview
Mannan-binding lectin serine protease 2 (MASP2)
- Target
- MASP2
- Molecular classification
- Enzyme, Peptidase S1 family of serine proteases
01
Overview
Mannan-binding lectin serine protease 2 (MASP2) is a key enzyme in the lectin pathway of the complement system. It activates complement components C4 and C2, leading to the formation of C3 convertase and the subsequent activation of the complement cascade. MASP-2 also plays a role in coagulation by cleaving prothrombin. It is considered a therapeutic target for inhibiting pathological activation of the lectin pathway.
- Other names
- MAP19MASP-2MASP1P1sMAPMannan binding lectin serine peptidase 2MBL associated serine protease 2MAP-2
02
Mechanism of action
Inhibition of MASP-2 activity via anti-MASP‑2 antibodies
03
Biological functions
Immune responseComplement activationCoagulation
04
Disease associations
MASP‑2 deficiencyInfection
05
Safety considerations
Potential for immunosuppression if complement activation is broadly inhibited.
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