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Target intelligence / Profile preview
Mannitol
- Molecular classification
- Sugar alcohol, Osmotic diuretic
01
Overview
Mannitol is an osmotic diuretic used to reduce cellular edema, particularly in the brain. It increases plasma osmolality, creating an osmotic gradient that draws water from intracellular and interstitial spaces into the vascular compartment, leading to diuresis and decreased intracranial pressure. It is used in the management of cerebral edema due to trauma or stroke, and for the reduction of elevated intracranial pressure.
- Other names
- D-MannitolManitolOsmitrol
02
Mechanism of action
Osmotically draws water from cells/tissues into vasculature, promoting diuresis and reducing intracranial pressure.
03
Biological functions
Osmotic agentDiuresis inductionIntracranial pressure reduction
04
Disease associations
Cerebral edemaElevated intracranial pressureAcute renal failure (prevention)Toxin elimination
05
Safety considerations
Electrolyte imbalance (hyponatremia, hypernatremia)Dehydration/hypovolemiaAcute kidney injury (AKI)Rebound increased intracranial pressure (ICP)Hypotension
06
Interacting drugs
Mannitol
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