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Target intelligence / Profile preview
Mannose-6-Phosphate Receptor (M6PR)
- Target
- M6PR
- Molecular classification
- Receptor, Type I integral membrane protein
01
Overview
The Mannose-6-Phosphate Receptor (M6PR) is a transmembrane protein responsible for transporting lysosomal enzymes from the Golgi apparatus to lysosomes. It recognizes and binds to mannose 6-phosphate (M6P) tags on newly synthesized acid hydrolases. There are two main types: cation-dependent (CD-MPR) and cation-independent (CI-MPR). The CI-MPR also binds insulin-like growth factor II (IGF-II) and modulates extracellular glycoproteins.
- Other names
- CD-MPRCation-Dependent Mannose-6-Phosphate ReceptorCI-MPRCation-Independent Mannose-6-Phosphate ReceptorIGF-II ReceptorIGFIIR
02
Mechanism of action
Receptor-mediated endocytosis and delivery of lysosomal enzymes.
03
Biological functions
Lysosomal enzyme targetingIntracellular traffickingLigand endocytosisGrowth factor signaling (IGF-II)
04
Disease associations
Lysosomal storage diseasesCancer
05
Interacting drugs
Mannose-6-Phosphate tagged enzymes
1 more in the full profile.
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