Target intelligence / Profile preview

Mannose-binding Lectin (MBL)

Target: MBL
Molecular classification: Collectin, C-type Lectin, Pattern Recognition Receptor

Overview

Mannose-binding lectin (MBL) is a soluble pattern recognition molecule and a key component of the innate immune system. As a collectin, it recognizes carbohydrate patterns on pathogens, activates the lectin pathway of complement, and enhances phagocytosis. MBL deficiency is common and associated with increased infection risk. Genetic variations influence serum levels and function.

Other names: Mannan-binding lectinMannan-binding protein

Biological functions

Pathogen recognitionComplement activation (lectin pathway)OpsonizationClearance of apoptotic cellsInnate immunity

Disease associations

Infection (increased susceptibility with deficiency)Autoimmune disorders (potential link)PneumoniaMeningitis

Safety considerations

Increased susceptibility to infections with deficiencyPotential role in autoimmune disease pathogenesis (complex and not fully understood)

Biomarkers

MBL serum levelsMBL gene mutations

Beyond the preview

Go deeper on Mannose-binding Lectin (MBL).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Mannose-binding Lectin (MBL).

Explore the full profile